Regioselective metal-free synthesis of sulfostyril-quinoline hybrid framework: Experimental and computational mechanistic insights

Abstract

Polycyclic sultams are widely encountered in both natural products and bioactive drug candidates. In cognizance to their synthetic and medicinal chemistry applications, the exploration of facile approaches remains at high demand. In the present work, a straightforward, efficient and operationally simple methodology has been developed. The coupling of β-chloroaldehyde with a diverse range of anilines as bis-nucleophile containing N–C–C fragment was achieved to deliver a sulfostyril-quinoline hybrid framework. The formation of target scaffolds bearing various substituents avoiding the need of column chromatographic purification represents one of the key advantages associated with this transfor..